Article
THI1, a protein involved in the biosynthesis of thiamin in Arabidopsis thaliana: structural analysis of THI1(A140V) mutant.
Biochimica et biophysica acta - 1 Jun 2014
Garcia Assuero F, Dyszy Fabio, Munte Claudia E, Demarco Ricardo, Beltramini Leila M, Oliva Glaucius, Costa-Filho Antonio J, Araujo Ana P U
Abstract excerpt
In eukaryotes, there are still steps of the vitamin B1 biosynthetic pathway not completely understood. In Arabidopsis thaliana, THI1 protein has been associated with the synthesis of the thiazole ring, a finding supported by the identification of a thiamine pyrophosphate (TPP)-like compound in its structure. Here, we investigated THI1 and its mutant THI1(A140V), responsible for the thiamin auxotrophy in a A....
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