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The asymmetric Pitx2 gene regulates gut muscular-lacteal development and protects against fatty liver disease

1 Nov 2021

Abstract excerpt

Intestinal lacteals are essential lymphatic channels for absorption and transport of dietary lipids and drive the pathogenesis of debilitating metabolic diseases. However, organ-specific mechanisms linking lymphatic dysfunction to disease etiology remain largely unknown. In this study, we uncover an intestinal lymphatic program that is linked to the left-right (LR) asymmetric transcription factor Pitx2. We show...

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PMID: 34818545
DOI: 10.1016/j.celrep.2021.110030

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