Article
Frequency of the frame-shifting CYP2D7 138delT polymorphism in a large, ethnically diverse sample population.
Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2007
Bhathena Anahita, Mueller Toby, Grimm David R, Idler Ken, Tsurutani Alan, Spear Brian B, Katz David A
Abstract excerpt
Cytochrome P450 2D7 (CYP2D7) has long been considered a pseudogene. A recent report described an indel polymorphism (CYP2D7 138delT) that causes a frameshift generating an open reading frame and functional protein. This polymorphism was observed in 6 of 12 samples from an Indian population. Individuals with the 138delT polymorphism expressed CYP2D7 protein from a brain-specific, alternatively spliced transcript...
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