Article
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
2006-03-01
Abstract excerpt
Life is the interplay between structure and energy, yet the role of energy deficiency in human disease has been poorly explored by modern medicine. Since the mitochondria use oxidative phosphorylation (OXPHOS) to convert dietary calories into usable energy, generating reactive oxygen species (ROS) as a toxic by‐product, it is hypothesized that mitochondrial dysfunction plays a central role in a wide range of age‐r...
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Identifiers and source
- Literature Corpus work
- 979912da-d8db-5a36-a707-f21cd4fd50b1
- DOI
- 10.1096/fasebj.20.5.a1474-c