Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41.

The FEBS journal - 1 Dec 2007

Fuhrman Christopher A, Warren Andrew D, Waring Alan J, Dutz Stephen M, Sharma Shantanu, Lehrer Robert I, Cole Amy L, Cole Alexander M

Abstract excerpt

Retrocyclin RC-101, a theta-defensin with lectin-like properties, potently inhibits infection by many HIV-1 subtypes by binding to the heptad repeat 2 (HR2) region of glycoprotein 41 (gp41) and preventing six-helix bundle formation. In the present study, we used in silico computational exploration to identify residues of HR2 that interacted with RC-101, and then analyzed the HIV-1 sequence database at Los Alamos...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Defensins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to HIV Envelope Protein gp41

Share to Peptides

Share to Protein Structure, Secondary

Share to Virus Replication

Source

Identifiers

PMID: 18028423
DOI: 10.1111/j.1742-4658.2007.06165.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41.PMID 18028423Read ↗

A compensatory mutation provides resistance to disparate HIV fusion inhibitor peptides and enhances membrane fusion.Semantic proximity Read ↗

HIV gp41 C-terminal Heptad Repeat Contains Multifunctional DomainsSemantic proximity Read ↗

A novel HIV-1 gp41 tripartite model for rational design of HIV-1 fusion inhibitors with improved antiviral activitySemantic proximity Read ↗

Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopesSemantic proximity Read ↗

Theta-Defensins Inhibit High-Risk Human Papillomavirus Infection Through Charge-Driven Capsid Clustering.Semantic proximity Read ↗

HIV-1 and its resistance to peptidic carbohydrate-binding agents (CBAs): an overview.Semantic proximity Read ↗

Mutations conferring resistance to human immunodeficiency virus type 1 fusion inhibitors are restricted by gp41 and Rev-responsive element functions.Semantic proximity Read ↗

HIV-1 resistance to the gp41-dependent fusion inhibitor C-34.Semantic proximity Read ↗

Alanine scanning mutagenesis of HIV-1 gp41 heptad repeat 1: insight into the gp120-gp41 interaction.Semantic proximity Read ↗

Significant differences in cell-cell fusion and viral entry between strains revealed by scanning mutagenesis of the C-heptad repeat of HIV gp41.Semantic proximity Read ↗

Sensitivity of Human Immunodeficiency Virus Type 1 to Fusion Inhibitors Targeted to the gp41 First Heptad Repeat Involves Distinct Regions of gp41 and Is Consistently Modulated by gp120 Interactions with the CoreceptorSemantic proximity Read ↗

Different susceptibility of human immunodeficiency virus type 1 to Env gp41-derived synthetic peptides corresponding to the C-terminal heptad repeat region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.