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Article

ADS-J1 inhibits HIV-1 infection and membrane fusion by targeting the highly conserved pocket in the gp41 NHR-trimer.

Biochimica et biophysica acta - 1 May 2014

Yu Fei, Lu Lu, Liu Qi, Yu Xiaowen, Wang Lili, He Elaine, Zou Peng, Du Lanying, Sanders Rogier W, Liu Shuwen, Jiang Shibo

Abstract excerpt

We previously identified a potent small-molecule human immunodeficiency virus type 1 (HIV-1) fusion inhibitor, termed ADS-J1, and hypothesized that it mainly targeted the hydrophobic pocket in the gp41 N-terminal heptad repeat (NHR) trimer. However, this hypothesis has been challenged by the fact that ADS-J1 cannot induce drug-resistance mutation in the gp41 pocket region. Therefore, we show herein that HIV-1...

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Identifiers

PMID: 24388952
DOI: 10.1016/j.bbamem.2013.12.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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