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High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area

19 Jul 2005

Abstract excerpt

BACKGROUND: Germline mutations in the BRCA1 and BRCA2 genes have been shown to account for the majority of hereditary breast and ovarian cancers. The purpose of our study was to estimate the incidence and spectrum of pathogenic mutations in BRCA1/2 genes in high-risk Czech families. METHODS: A total of 96 Czech families with recurrent breast and/or ovarian cancer and 55 patients considered to be at high-risk but...

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PMID: 16168118
DOI: 10.1186/bcr1282

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