Article
The mating type switch-activating protein Sap1 Is required for replication fork arrest at the rRNA genes of fission yeast.
Molecular and cellular biology - 1 Oct 2005
Mejía-Ramírez Eva, Sánchez-Gorostiaga Alicia, Krimer Dora B, Schvartzman Jorge B, Hernández Pablo
Abstract excerpt
Schizosaccharomyces pombe rRNA genes contain three replication fork barriers (RFB1-3) located in the nontranscribed spacer. RFB2 and RFB3 require binding of the transcription terminator factor Reb1p to two identical recognition sequences that colocalize with these barriers. RFB1, which is the strongest of the three barriers, functions in a Reb1p-independent manner, and cognate DNA-binding proteins for this...
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