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Article

Glucose 6-phosphate release of wild-type and mutant human brain hexokinases from mitochondria.

The Journal of biological chemistry - 18 Nov 2005

Skaff D Andrew, Kim Chang Sup, Tsai Henry J, Honzatko Richard B, Fromm Herbert J

Abstract excerpt

One molecule of glucose 6-phosphate inhibits brain hexokinase (HKI) with high affinity by binding to either one of two sites located in distinct halves of the enzyme. In addition to potent inhibition, glucose 6-phosphate releases HKI from the outer leaflet of mitochondria; however, the site of glucose 6-phosphate association responsible for the release of HKI is unclear. The incorporation of a C-terminal...

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Identifiers

PMID: 16166083
DOI: 10.1074/jbc.M506943200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glucose 6-phosphate release of wild-type and mutant human brain hexokinases from mitochondria.PMID 16166083Read ↗

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Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II.Semantic proximity Read ↗

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