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Article

ATP-binding site of human brain hexokinase as studied by molecular modeling and site-directed mutagenesis.

Biochemistry - 8 Oct 1996

Zeng C, Aleshin A E, Hardie J B, Harrison R W, Fromm H J

Abstract excerpt

The interaction of ATP with the active site of hexokinase is unknown since the crystal structure of the hexokinase-ATP complex is unavailable. It was found that the ATP binding site of brain hexokinase is homologous to that of actin, heat shock protein hsc70, and glycerol kinase. On the basis of these similarities, the ATP molecule was positioned in the catalytic domain of human brain hexokinase, which was...

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Identifiers

PMID: 8855953
DOI: 10.1021/bi960750e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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