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Article

Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis.

The Journal of biological chemistry - 20 Nov 2009

Tang Fangming, Kokontis John, Lin Yuting, Liao Shutsung, Lin Anning, Xiang Jialing

Abstract excerpt

The male hormone androgen is a growth/survival factor for its target tissues or organs. Yet, the underlying mechanism is incompletely understood. Here, we report that androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. Inhibition by androgen requires the transcription activity of androgen receptor (AR) and de novo protein synthesis. Androgen.AR induces expression of p21...

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Source

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Identifiers

PMID: 19723627
DOI: 10.1074/jbc.M109.042994
PMCID: PMC2781650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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