Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2003

Lee Soo Ok, Lou Wei, Hou Min, de Miguel Fernando, Gerber Lizabeth, Gao Allen C

Abstract excerpt

PURPOSE: Prostate cancer frequently progresses from an initial androgen dependence to androgen independence, rendering the only effective androgen ablation therapy useless. The mechanism underlying the androgen-independent progression is incompletely understood. Interleukin (IL)-6 has been implicated in this androgen-independent progression. In this study, we tested whether IL-6 induces androgen-independent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Coloring Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-6

Share to Prostatic Neoplasms

Share to STAT3 Transcription Factor

Share to Tetrazolium Salts

Share to Thiazoles

Share to Trans-Activators

Source

Identifiers

PMID: 12538490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells.PMID 12538490Read ↗

Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells.Semantic proximity Read ↗

STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP.Semantic proximity Read ↗

Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation.Semantic proximity Read ↗

Identification of an IL-1-induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR- PCa cells.Semantic proximity Read ↗

Establishment of a highly tumorigenic LNCaP cell line having inflammatory cytokine resistance.Semantic proximity Read ↗

RELA is Sufficient to Mediate Interleukin-1 (IL-1) Repression of Androgen Receptor Expression and Activity in LNCaP Disease Progression ModelSemantic proximity Read ↗

CXCL12 Activates a Robust Transcriptional Response in Human Prostate Epithelial CellsSemantic proximity Read ↗

RELA is sufficient to mediate interleukin‐1 repression of androgen receptor expression and activity in an LNCaP disease progression modelSemantic proximity Read ↗

Soy Isoflavones Alter Expression of Genes Associated with Cancer Progression, Including Interleukin-8, in Androgen-Independent PC-3 Human Prostate Cancer CellsSemantic proximity Read ↗

Imaging of bioluminescent LNCaP-luc-M6 tumors: a new animal model for the study of metastatic human prostate cancer.Semantic proximity Read ↗

Tumor suppressor function of androgen receptor coactivator ARA70alpha in prostate cancer.Semantic proximity Read ↗

Interleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.