Article
Effects of nitric oxide donors on cybrids harbouring the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) A3243G mitochondrial DNA mutation.
The Biochemical journal - 15 Oct 2005
Sandhu Jagdeep K, Sodja Caroline, McRae Kevan, Li Yan, Rippstein Peter, Wei Yau-Huei, Lach Boleslaw, Lee Fay, Bucurescu Septimiu, Harper Mary-Ellen, Sikorska Marianna
Abstract excerpt
Reactive nitrogen and oxygen species (O2*-, H2O2, NO* and ONOO-) have been strongly implicated in the pathophysiology of neurodegenerative and mitochondrial diseases. In the present study, we examined the effects of nitrosative and/or nitrative stress generated by DETA-NO {(Z)-1-[2-aminoethyl-N-(...
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