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Free radicals-mediated damage in transmitochondrial cells harboring the T14487C mutation in the ND6 gene of mtDNA.

FEBS letters - 19 Dec 2005

Gonzalo Ricardo, Garcia-Arumi Elena, Llige David, Marti Ramon, Solano Abelardo, Montoya Julio, Arenas Joaquín, Andreu Antonio L

Abstract excerpt

We have studied the production of reactive oxygen species (ROS) in transmitochondrial cells, harboring homoplasmic levels of the T14487C mtDNA mutation in the ND6 gene of mitochondrial DNA (mtDNA). Previous work has shown that this mutation causes complex I deficiency. Here, we show that this mutation causes an overproduction of ROS leading to an increase in the oxidation of lipids and mtDNA without modification...

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Identifiers

PMID: 16337195
DOI: 10.1016/j.febslet.2005.11.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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