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Article

Pyrosequencing: history, biochemistry and future.

Clinica chimica acta; international journal of clinical chemistry - 1 Jan 2006

Ahmadian Afshin, Ehn Maria, Hober Sophia

Abstract excerpt

BACKGROUND: Pyrosequencing is a DNA sequencing technology based on the sequencing-by-synthesis principle. METHODS: The technique is built on a 4-enzyme real-time monitoring of DNA synthesis by bioluminescence using a cascade that upon nucleotide incorporation ends in a detectable light signal (bioluminescence). The detection system is based on the pyrophosphate released when a nucleotide is introduced in the...

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PMID: 16165119
DOI: 10.1016/j.cccn.2005.04.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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