Article
Post-translational self-hydroxylation: a probe for oxygen activation mechanisms in non-heme iron enzymes.
Biochemical and biophysical research communications - 9 Dec 2005
Farquhar Erik R, Koehntop Kevin D, Emerson Joseph P, Que Lawrence
Abstract excerpt
Recent years have seen considerable evolution in our understanding of the mechanisms of oxygen activation by non-heme iron enzymes, with high-valent iron-oxo intermediates coming to the forefront as formidably potent oxidants. In the absence of substrate, the generation of vividly colored chromophores deriving from the self-hydroxylation of a nearby aromatic amino acid for a number of these enzymes has afforded...
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