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Article

Molecular analysis of thiopurine S-methyltransferase alleles in Taiwan aborigines and Taiwanese.

Journal of clinical pharmacy and therapeutics - 1 Feb 2006

Lu H-F, Shih M-C, Chang Y-S, Chang J-Y, Ko Y-C, Chang S-J, Chang J-G

Abstract excerpt

BACKGROUND: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme involved in the metabolism of these thiopurine drugs. Methylation of thiopurine drugs by TPMT competes with the formation of their active 6-thioguanine nucleotide metabolite, thereby potentially modulating the therapeutic and toxic effects of these drugs. OBJECTIVE: To analyze the thiopurine S-methyltransferase allelic frequencies in Taiwan...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16476125
DOI: 10.1111/j.1365-2710.2006.00707.x

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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