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Article

Bim Nuclear Translocation and Inactivation by Viral Interferon Regulatory Factor

5 Aug 2010

Abstract excerpt

Viral replication efficiency is in large part governed by the ability of viruses to counteract pro-apoptotic signals induced by infection of the host cell. Human herpesvirus 8 (HHV-8) uses several strategies to block the host's innate antiviral defenses via interference with interferon and apoptotic signaling. Contributors include the four viral interferon regulatory factors (vIRFs 1-4), which function in...

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PMID: 20700448
DOI: 10.1371/journal.ppat.1001031

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