Article
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.
Molecular cell - 1 Mar 1999
Puthalakath H, Huang D C, O'Reilly L A, King S M, Strasser A
Abstract excerpt
Bcl-2 family members that have only a single Bcl-2 homology domain, BH3, are potent inducers of apoptosis, and some appear to play a critical role in developmentally programmed cell death. We examined the regulation of the proapoptotic activity of the BH3-only protein Bim. In healthy cells, most Bim molecules were bound to LC8 cytoplasmic dynein light chain and thereby sequestered to the microtubule-associated...
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