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Article

Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A.

The New England journal of medicine - 15 Sept 2005

Skinner Michael A, Moley Jeffrey A, Dilley William G, Owzar Kouros, Debenedetti Mary K, Wells Samuel A

Abstract excerpt

BACKGROUND: Medullary thyroid carcinoma is the most common cause of death in patients with multiple endocrine neoplasia (MEN) type 2A (MEN-2A) or type 2B or familial medullary thyroid carcinoma. We sought to determine whether total thyroidectomy in asymptomatic young members of kindreds with MEN-2A who had a mutated allele of the RET proto-oncogene could prevent or cure medullary thyroid carcinoma. METHODS: A...

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PMID: 16162881
DOI: 10.1056/NEJMoa043999

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RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Prophylactic thyroidectomy in multiple endocrine neoplasia: the impact of molecular mechanisms of RET proto-oncogene.Semantic proximity Read ↗

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