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[Prophylactic thyroidectomy in medullary thyroid cancer].

Bulletin de l'Academie nationale de medecine - 1 Oct 2012

Peix Jean-Louis, Lifante Jean Christophe, Borson Chazot Françoise, Giraud Sophie

Abstract excerpt

Medullary thyroid cancer (MTC) is genetically determined in 30% to 35% of cases, notably through multiple mutations in the RET protooncogene located on chromosome 10, for which a genotype-phenotype relationship determines age of onset. There are three phenotypes: MEN 2 A and B, and isolated familial MTC. The type of mutation determines 3 levels of aggressiveness. Current guidelines recommend thyroidectomy during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Endocrine Neoplasia Type 2a

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Source

Identifiers

PMID: 23815012

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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