Article
Fusion of the <i>SEC31L1</i> and <i>ALK</i> genes in an inflammatory myofibroblastic tumor
20 Dec 2005
Abstract excerpt
Inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic spindle cells and infiltrating inflammatory cells. Cytogenetic analyses have revealed that a subgroup of IMT, in particular among children and young adults, harbors clonal chromosomal rearrangements involving chromosome band 2p23. Further, molecular genetic studies have shown that these rearrangements target the ALK gene, serving...
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