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Assessment of <i>ALK</i> Fusions in Uncommon Inflammatory Myofibroblastic Tumors With <i>ALK</i> IHC Positivity but FISH-Equivocal Findings by Targeted RNA Sequencing

18 Jan 2022

Abstract excerpt

CONTEXT.—: Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) are common methods to detect ALK status in inflammatory myofibroblastic tumors (IMTs). However, equivocal ALK FISH signals and inconsistency between FISH and IHC are occasionally observed. OBJECTIVE.—: To study the inconsistency between FISH and IHC, and clarify ALK status in IMT by targeted RNA sequencing (RNAseq). DESIGN.—: In...

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PMID: 35041745
DOI: 10.5858/arpa.2021-0230-oa

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