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Article

<i>ROS1</i> Fusions in Cancer: A Review

3 Jun 2016

Abstract excerpt

The ROS1 gene belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. A literature review identified a ROS1 fusion in 2.54% of the patients with lung adenocarcinoma and even higher frequencies in spitzoid neoplasms and inflammatory myofibroblastic tumors. At present, 26 genes were found to fuse with ROS1, some of them already known to fuse with RET and ALK. All the fusion proteins retain the...

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Identifiers

PMID: 27256160
DOI: 10.2217/fon-2016-0050

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