Article
Polymorphism of the mouse gene for the interleukin 10 receptor alpha chain (Il10ra) and its association with the autoimmune phenotype.
Immunogenetics - 1 Oct 2005
Qi Zan-Mei, Wang Jun, Sun Zheng-Rong, Ma Feng-Mao, Zhang Qing-Rui, Hirose Sachiko, Jiang Yi
Abstract excerpt
Several studies suggest that interleukin (IL)-10 pathway is involved in murine lupus, while no linkage of IL-10 gene polymorphism to disease susceptibility has been reported in studies with lupus-prone mice. Since IL-10 functions through the specific IL-10 receptor alpha (IL-10RA) chain and the IL-10RA gene (Il10ra) is linked to the susceptibility loci of atopic dermatitis and Crohn's disease identified using...
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