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Variola virus immune evasion design: Expression of a highly efficient inhibitor of human complement

28 May 2002

Abstract excerpt

Variola virus, the most virulent member of the genus Orthopoxvirus, specifically infects humans and has no other animal reservoir. Variola causes the contagious disease smallpox, which has a 30-40% mortality rate. Conversely, the prototype orthopoxvirus, vaccinia, causes no disease in immunocompetent humans and was used in the global eradication of smallpox, which ended in 1977. However, the threat of smallpox...

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PMID: 12034872
DOI: 10.1073/pnas.112220499

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