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Article

Inhibition of the Complement Cascade by the Major Secretory Protein of Vaccinia Virus

9 Nov 1990

Abstract excerpt

The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the...

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PMID: 2237434
DOI: 10.1126/science.2237434

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Related research

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Inhibition of the Complement Cascade by the Major Secretory Protein of Vaccinia VirusPMID 2237434Read ↗

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Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectorsSemantic proximity Read ↗

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