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Extracellular enveloped vaccinia virus is resistant to complement because of incorporation of host complement control proteins into its envelope

23 Jun 1998

Abstract excerpt

Vaccinia virus (VV) produces two antigenically and structurally distinct infectious virions, intracellular mature virus (IMV) and extracellular enveloped virus (EEV). Here we have investigated the resistance of EEV and IMV to neutralization by complement in the absence of immune antibodies. When EEV is challenged with complement from the same species as the cells used to grow the virus, EEV is resistant to...

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PMID: 9636186
DOI: 10.1073/pnas.95.13.7544

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