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Article

Stoichiometry of envelope glycoprotein trimers in the entry of human immunodeficiency virus type 1.

Journal of virology - 1 Oct 2005

Yang Xinzhen, Kurteva Svetla, Ren Xinping, Lee Sandra, Sodroski Joseph

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Envs) function as a trimer, mediating virus entry by promoting the fusion of the viral and target cell membranes. HIV-1 Env trimers induce membrane fusion through a pH-independent pathway driven by the interaction between an Env trimer and its cellular receptors, CD4 and CCR5/CXCR4. We studied viruses with mixed heterotrimers of wild-type and...

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Source

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Identifiers

PMID: 16160141
DOI: 10.1128/JVI.79.19.12132-12147.2005
PMCID: PMC1211524

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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