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Article

Stoichiometric parameters of HIV-1 entry.

Virology - 1 Jan 2015

Zarr Melissa, Siliciano Robert

Abstract excerpt

During HIV type 1 (HIV-1) entry, trimers of gp120 bind to CD4 and either the CCR5 or CXCR4 coreceptor on the target cell. The stoichiometric parameters associated with HIV-1 entry remain unclear. Important unanswered questions include: how many trimers must attach to CD4 molecules, how many must bind coreceptors, and how many functional gp120 subunits per trimer are required for entry? We performed single round...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

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Share to Human Immunodeficiency Virus Proteins

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Source

Identifiers

PMID: 25463598
DOI: 10.1016/j.virol.2014.10.007

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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