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Article

Stoichiometric parameters of HIV-1 entry.

Virology - 1 Jan 2015

Zarr Melissa, Siliciano Robert

Abstract excerpt

During HIV type 1 (HIV-1) entry, trimers of gp120 bind to CD4 and either the CCR5 or CXCR4 coreceptor on the target cell. The stoichiometric parameters associated with HIV-1 entry remain unclear. Important unanswered questions include: how many trimers must attach to CD4 molecules, how many must...

Read the complete abstract on PubMed

Topics

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Share to CD4 Antigens
Share to Genes, Viral
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

Share to Host-Pathogen Interactions

Share to Human Immunodeficiency Virus Proteins

Share to Receptors, HIV

Share to Virus Internalization

Source

Identifiers

PMID: 25463598
DOI: 10.1016/j.virol.2014.10.007

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25463598-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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