Article
MMP-9 microsatellite polymorphism: association with the progression of intima-media thickening and constrictive remodeling of carotid atherosclerotic plaques.
Atherosclerosis - 1 Oct 2005
Fiotti Nicola, Altamura Nicola, Fisicaro Maurizio, Carraro Nicola, Adovasio Roberto, Sarra Vittoria Maria, Uxa Laura, Guarnieri Gianfranco, Baxter Bernard Timothy, Giansante Carlo
Abstract excerpt
Intima-media thickening (IMT) of carotid arteries and constrictive remodeling (CR) of atherosclerotic plaques are vascular pathologic characteristics that precede the onset of vascular events. SMC migration and proliferation are linked both to IMT and CR and are matrix metalloproteinase 9 (MMP-9) dependent. A genetic polymorphism (PM) of MMP-9, a CA (13-27) microsatellite in the promoter region, which accounts...
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