Article
Serum levels and polymorphisms of matrix metalloproteinases (MMPs) in carotid artery atherosclerosis: higher MMP-9 levels are associated with plaque vulnerability.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Feb 2014
Silvello Daiane, Narvaes Luciane Barreneche, Albuquerque Luciano Cabral, Forgiarini Luiz Felipe, Meurer Luise, Martinelli Nidiane Carla, Andrades Michael Everton, Clausell Nadine, dos Santos Kátia Gonçalves, Rohde Luis Eduardo
Abstract excerpt
CONTEXT: Matrix metalloproteinases are involved in atherosclerosis and plaque vulnerability. OBJECTIVE: To investigate serum levels and genetic polymorphisms of matrix metalloproteinases (MMPs) -1, -3 and -9 in patients submitted to carotid endarterectomy. METHODS: Genetic polymorphisms were evaluated using polymerase chain reaction (PCR-RFLP); serum levels were measured using ELISA; histological sections were...
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