Article
A normotriglyceridemic, low HDL-cholesterol phenotype is characterised by elevated oxidative stress and HDL particles with attenuated antioxidative activity.
Atherosclerosis - 1 Oct 2005
Kontush Anatol, de Faria Eliana Cotta, Chantepie Sandrine, Chapman M John
Abstract excerpt
OBJECTIVE: Low levels of high density lipoprotein-cholesterol (HDL-C) are highly prevalent in subjects presenting premature atherosclerosis. It is indeterminate as to whether high cardiovascular risk in low HDL-C subjects occurs concomitantly with elevated oxidative stress and/or with biologically dysfunctional HDL particles. METHODS AND RESULTS: Systemic oxidative stress (as plasma 8-isoprostanes) was 2.3-fold...
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