Article
Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme.
Science (New York, N.Y.) - 3 Aug 2001
Griffitts J S, Whitacre J L, Stevens D E, Aroian R V
Abstract excerpt
The development of resistance is the main threat to the long-term use of toxins from Bacillus thuringiensis (Bt) in transgenic plants. Here we report the cloning of a Bt toxin resistance gene, Caenorhabditis elegans bre-5, which encodes a putative beta-1,3-galactosyltransferase. Lack of bre-5 in the intestine led to resistance to the Bt toxin Cry5B. Wild-type but not bre-5 mutant animals were found to uptake...
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