Article
Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1.
Journal of human genetics - 1 Jan 2005
Ellis Justine A, Panagiotopoulos Sianna, Akdeniz Aysel, Jerums George, Harrap Stephen B
Abstract excerpt
Androgens determine male secondary sexual characteristics and influence a variety of metabolic pathways. Circulating levels of androgens are highly heritable; however, the genes involved are largely unknown. The 5alpha-reductase enzymes types 1 and 2 responsible for converting testosterone to the more potent androgen dihydrotestosterone are encoded by the SRD5A1 and SRD5A2 genes, respectively. We performed...
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