M1 RNA is important for the in-cell solubility of its cognate C5 protein: Implications for RNA-mediated protein folding.

Abstract excerpt

It is one of the fundamental questions in biology how proteins efficiently fold into their native conformations despite off-pathway events such as misfolding and aggregation in living cells. Although molecular chaperones have been known to assist the de novo folding of certain types of proteins, the role of a binding partner (or a ligand) in the folding and in-cell solubility of its interacting protein still...

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