Article
[Modulation of mRNAs P450 and hepatocarcinogenesis promotion].
Bulletin du cancer - 1 Jan 1990
Lechner M C, Ribeiro V L, Henrique D, Barroso M, Cravino M M
Abstract excerpt
The adaptive response of the liver to phenobarbital is characterized by a strong cell hypertrophy and coordinate induction of specific P450 forms (IIB1, 2; IIC7, IIIA1). The pattern of active mRNA is significantly changed, demonstrating the establishment of PB phenotype. Employed as a promoting a...
Topics
- Animals
- Carcinogens
- Cytochrome P-450 Enzyme System
- Enzyme Induction
- Liver
- Liver Neoplasms, Experimental
- Phenobarbital
- Phenotype
- RNA, Messenger
- Rats