Article
Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer's disease.
Neurobiology of aging - 1 Sept 2006
Chapuis Julien, Tian Jinzhou, Shi Jing, Bensemain Faiza, Cottel Dominique, Lendon Corinne, Amouyel Philippe, Mann David, Lambert Jean-Charles
Abstract excerpt
Numerous observations indicate that cerebrovascular dysfunction contributes to cognitive decline and neurodegeneration in AD. Converging evidence points to a pivotal role for vascular endothelial growth factor (VEGF) in neuronal protection, and the lack of activity of this in neurodegenerative disorders. The VEGF gene is located at 6p21.3, a site several studies have shown to have significant linkage with AD, and...
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