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Article

Analysis of endothelial gene polymorphisms in Spanish patients with vascular dementia and Alzheimer´s disease.

Scientific reports - 18 Aug 2023

Manso-Calderón Raquel, Cacabelos-Pérez Purificación, Sevillano-García M Dolores, Herrero-Prieto M Elisa, González-Sarmiento Rogelio

Abstract excerpt

There is increasing evidence for the involvement of blood-brain barrier (BBB) in vascular dementia (VaD) and Alzheimer´s disease (AD) pathogenesis. However, the role of endothelial function-related genes in these disorders remains unclear. We evaluated the association of four single-nucleotide polymorphisms (VEGF, VEGFR2 and NOS3) with diagnosis and rate of cognitive decline in AD and VaD in a Spanish...

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Identifiers

PMID: 37596325
DOI: 10.1038/s41598-023-39576-7
PMCID: PMC10439194

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