Elimination of indigenous linear plasmids in Streptomyces hygroscopicus var. jinggangensis and Streptomyces sp. FR008 to increase validamycin A and candicidin productivities.

Abstract excerpt

Giant linear plasmids, which replicate independently of the chromosomes, widely exist in actinobacteria. Previous studies mostly focused on the replication and evolution of the linear plasmids or the secondary metabolite gene clusters and the resistance gene clusters therein. However, the relationships of the linear plasmids to the productivities of secondary metabolites have not been studied. In this work, we...

Topics

• Bacterial Proteins
• Candicidin
• Gene Expression Regulation, Bacterial
• Genetic Complementation Test
• Inositol
• Multigene Family
• Mutation
• Plasmids
• Promoter Regions, Genetic
• Secondary Metabolism