Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors.

Journal of cellular biochemistry - 1 Dec 2005

Al Sarraj Jude, Vinson Charles, Han Jiahuai, Thiel Gerald

Abstract excerpt

Tetrahydrobiopterin is an essential cofactor for the phenylalanine, tyrosine and tryptophan hydroxylases, and the family of nitric oxide synthases. The initial and rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin is GTP cyclohydrolase I. The proximal promoter of the human GTP cyclohydrolase I gene contains the sequence motif 5'-TGACGCGA-3', resembling a cAMP response element (CRE). The objective of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 2
Share to Cyclic AMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic AMP Response Element-Binding Protein

Share to GTP Cyclohydrolase

Share to Leucine Zippers

Share to MAP Kinase Kinase Kinase 1

Share to p38 Mitogen-Activated Protein Kinases

Share to Proto-Oncogene Proteins c-jun

Source

Identifiers

PMID: 16149046
DOI: 10.1002/jcb.20580

Genes

ATF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors.PMID 16149046Read ↗

Differential regulation of three members of the ATF/CREB family of DNA-binding proteins.Semantic proximity Read ↗

Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.Semantic proximity Read ↗

The N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP.Semantic proximity Read ↗

Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency.Semantic proximity Read ↗

Identification of a novel transcriptional regulatory element within the promoter region of the keratinocyte growth factor gene that mediates inducibility to cyclic AMP.Semantic proximity Read ↗

Dominant negative mutants of transcription factor mXBP (CRE-BP1, ATF-2).Semantic proximity Read ↗

Structural determinants outside of the leucine zipper influence the interactions of CREB and ATF-2: interaction of CREB with ATF-2 blocks E1a-ATF-2 complex formation.Semantic proximity Read ↗

Regulation of Gene Expression by cGMP-dependent Protein KinaseSemantic proximity Read ↗

Two cysteine residues in the DNA-binding domain of CREB control binding to CRE and CREB-mediated gene expression.Semantic proximity Read ↗

Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements.Semantic proximity Read ↗

Functional interactions between GTP cyclohydrolase I and tyrosine hydroxylase in Drosophila.Semantic proximity Read ↗

Electrostatic control of half-site spacing preferences by the cyclic AMP response element-binding protein CREB.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.