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Article

Functional interactions between GTP cyclohydrolase I and tyrosine hydroxylase in Drosophila.

Journal of neurogenetics - 1 Apr 2000

Krishnakumar S, Burton D, Rasco J, Chen X, O'Donnell J

Abstract excerpt

Tyrosine hydroxylase requires the regulatory cofactor, tetrahydrobiopterin, for catecholamine biosynthesis. Because guanosine triphosphate cyclohydrolase I is the rate limiting enzyme for the synthesis of this cofactor, it has a key role in catecholamine production. We show that GTP cyclohydrolase and tyrosine hydroxylase (TH) are co-localized in the Drosophila central nervous system. Mutations in the Punch...

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Identifiers

PMID: 10938545
DOI: 10.3109/01677060009083474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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