Article
The negative dominant effects of T340M mutation on mammalian pyruvate kinase.
The Journal of biological chemistry - 12 Jun 1998
Friesen R H, Lee J C
Abstract excerpt
A fundamental issue in allosteric regulatory enzymes is the identification of pathways of signal transmission. Rabbit muscle and kidney pyruvate kinase isozymes are ideal to address this issue because these isozymes exhibit different enzymatic regulatory patterns, and the sequence differences bet...
Topics
- Adenosine Diphosphate
- Allosteric Regulation
- Animals
- Binding Sites
- Circular Dichroism
- Fructosediphosphates
- Isoenzymes
- Kidney
- Kinetics
- Models, Molecular
- Muscles
- Mutagenesis, Site-Directed
- Mutation
- Phosphoenolpyruvate
- Pyruvate Kinase
- Rabbits
- Ultracentrifugation