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Article

Comparative study of protein and mRNA expression during osteoclastogenesis

7 Sept 2005

Abstract excerpt

Osteoclasts, the bone-digesting cells, are key players in bone remodeling. To identify proteins potentially involved in osteoclast function, we analyzed the patterns of protein expression during osteoclastogenesis by2-D DIGE. As a model system we used the mouse myeloid Raw 264.7 cell line that differentiates in vitro into osteoclasts upon treatment with specific growth factors. In 2-D DIGE, we identified 86 up-...

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PMID: 16145714
DOI: 10.1002/pmic.200402059

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