Article
Gene expression profiling of osteoclast differentiation by combined suppression subtractive hybridization (SSH) and cDNA microarray analysis.
DNA and cell biology - 1 Aug 2002
Rho Jaerang, Altmann Curtis R, Socci Nicholas D, Merkov Lubomir, Kim Nacksung, So Hongseob, Lee Okbok, Takami Masamichi, Brivanlou Ali H, Choi Yongwon
Abstract excerpt
Bone homeostasis is maintained by the balanced action of bone-forming osteoblasts and bone-resorbing osteoclasts. Multinucleated, mature osteoclasts develop from hematopoietic stem cells via the monocyte-macrophage lineage, which also give rise to macrophages and dendritic cells. Despite their distinct physiologic roles in bone and the immune system, these cell types share many molecular and biochemical features....
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