The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria

Abstract excerpt

Antigenic variation in the human malaria parasite Plasmodium falciparum involves sequential and mutually exclusive expression of members of the var multi-gene family and appears to follow a non-random pattern. In this study, using a detailed in vitro gene transcription analysis of the culture-adapted HB3 strain of P. falciparum, we show that antigenic switching is governed by a global activation hierarchy...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aquaculture disease management and microbiota
• Share to Invertebrate Immune Response Mechanisms
• Share to Malaria Research and Control