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Article

Use of molecular beacons for rapid, real-time, quantitative monitoring of cytotoxic T-lymphocyte epitope mutations in simian immunodeficiency virus.

Journal of clinical microbiology - 1 Sept 2005

Peyerl Fred W, Barouch Dan H, Bazick Heidi S, Manuel Edwin, Letvin Norman L

Abstract excerpt

Immune pressure on lentiviruses exerted by cytotoxic T lymphocytes (CTL) selects for virus CTL epitope mutations. Currently employed methods for monitoring emerging CTL epitope mutations rely on the labor-intensive and time-consuming techniques of virus population or clonal sequencing. Here we describe the development of a high-throughput quantitative reverse transcription-PCR assay that facilitates large-scale...

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Identifiers

PMID: 16145140
DOI: 10.1128/JCM.43.9.4773-4779.2005
PMCID: PMC1234110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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