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Article

5-fluorouracil forward mutation assay in Salmonella: determination of mutational target and spontaneous mutational spectra.

Mutation research - 15 Oct 2005

Glaab Warren E, Mitchell Laurie S, Miller Judith E, Vlasakova Katerina, Skopek Thomas R

Abstract excerpt

A forward mutation assay in Salmonella typhimurium that selects for 5-fluoruracil (FU) resistance has been developed. The two genes possibly involved in FU resistance, the uracil phosphoribosyl transferase gene (upp) and the uracil transport protein (uraA), have been cloned from S. typhimurium and sequenced. One hundred percent of FU-resistant clones display sequence changes in the upp gene, indicating that its...

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Identifiers

PMID: 16143351
DOI: 10.1016/j.mrfmmm.2005.05.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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