Article
Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs.
Oncology reports - 1 Oct 2005
Katoh Masuko, Katoh Masaru
Abstract excerpt
SNAI1, SNAI2, and SNAI3 genes, encoding transcriptional repressors implicated in epithelial mesenchymal transition (EMT), are human homologs of Drosophila snail (sna) and slug genes. SNAI1 represses transcription of CDH1 (E-cadherin) gene. SNAI2 induces the first phase of EMT, including desmosome dissociation, cell spreading, and initiation of cell separation. Because SNAI family proteins are implicated in EMT...
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