Article
Prostaglandin A2 Acts as a Transactivator for NOR1 (NR4A3) within the Nuclear Receptor Superfamily
1 Jan 2005
Abstract excerpt
Within the nuclear receptor superfamily, Nur77, Nurr1, and NOR1 constitute the nuclear receptor subfamily 4 group A. Modulation of NOR1 function would be therapeutic potential for diseases related to dysfunction of NOR1, including extraskeletal myxoid chondrosarcoma and autoimmune diseases. By screening arachidonate metabolites for their capacity of transcriptional activation, we have identified prostaglandin...
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